Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents
AssigneeN30 Pharmaceuticals, Inc.
InventorsJan Wasley, Gary J. Rosenthal, Xicheng Sun, Sarah Strong, Jian Qiu
Life of this patent
Estimating the term…
Abstract
The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
Claims8
A method of treatment of heart failure, atherosclerosis, degenerative neurologic disorders, arthritis and liver injury (ischemic or alcoholic) comprising administering a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof:
- wherein
- Ar1 and Ar2 are independently selected from the group consisting of aryl, substituted aryl, heteroaryl and substituted heteroaryl;
- X is selected from the group consisting of C or N;
- Y is C when X is N, and N when X is C;
- and
- n is 0-3;
- to a patient in need thereof.
A method of making a pharmaceutical composition comprising the step of combining a compound of formula I or a pharmaceutically acceptable salt thereof:
- wherein
- Ar1 and Ar2 are independently selected from the group consisting of aryl, substituted aryl, heteroaryl and substituted heteroaryl;
- X is selected from the group consisting of C or N;
- Y is C when X is N, and N when X is C;
- and
- n is 0-3;
- with a pharmaceutically accepted carrier or excipient.
Dependencies are inferred from the claim text.