Pyridone derivatives and their use in the treatment, ameloriation or prevention of a viral disease

A compound having the general formula (II),

• wherein
• X20 is NR25, N(R25)C(O), C(O)NR25, O, C(O), C(O)O, OC(O);
• N(R25)SO2, SO2N(R25), S, SO, or SO2;
• R20 is —H, a —C1-6 alkyl group or a —C(O)—C1-6 alkyl group;
• R21 is —H, a —C1-6 alkyl group, or a —C1-6 alkyl group which is substituted by one or more halogen atoms;
• R22 is —H, a —C1-6 alkyl group, or a —C1-6 alkyl group which is substituted by one or more halogen atoms;
• or wherein R21 and R22 can be joined together to form a 3- to 7-membered carbo- or heterocyclic ring;
• R23 is —R26, or —X20—R26;
• R24 is H, or a C1-6 alkyl group;
• R25 is —H, -(optionally substituted C1-6 alkyl), -(optionally substituted C3-7cycloalkyl), -(optionally substituted aryl), —C1-4 alkyl-(optionally substituted C3-7 cycloalkyl), or —C1-4 alkyl-(optionally substituted aryl);
• R26 is -(optionally substituted hydrocarbon group which contains from 5 to 20 carbon atoms and optionally 1 to 4 heteroatoms selected from O, N and S and which contains at least one ring);
• R27 is —H, —C1-6 alkyl, or —(CH2CH2O)rH;
• R28 is —H, or —C1-6 alkyl;
• R is independently selected from —C1-6 alkyl, —C(O)—C1-6 alkyl, -Hal, —CF3, —CN,
• —COOR27, —OR27, —(CH2)qNR27R28, —C(O)—NR27R28, and —NR27—C(O)—C1-6 alkyl;
• q is 0 to 4;
• and
• r is 1 to 3;
• wherein the alkyl group, aryl group, hydrocarbon group and/or cycloalkyl group can be optionally substituted with one or more substituents R,
• or a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof.