Composition for treating atherosclerosis and a preparation method thereof

A method for increasing a reproduction of a peroxisome proliferator activated receptor gamma (PPARγ) in a subject, comprising a step of:

• administering to the subject an effective amount of a chalcone compound represented by Formula I:
• to increase the reproduction of the PPARγ, wherein R1 is a first hydrogen, each of R2 to R5 is selected from a group consisting of a second hydrogen, a first hydroxide and a halogen, each of R6, R7, R9 and R10 is selected from a group consisting of a third hydrogen, a second hydroxide, a C1 to C20 alkoxy group and a benzyloxy group, and R8 is selected from a group consisting of a fourth hydrogen, a C1 to C20 alkyl group and a benzyl group.

A method for inhibiting at least one of a cell proliferation of human aortic smooth muscle cells and an inflammation of a subject, comprising a step of:

• administering to the subject an effective amount of a chalcone compound represented by Formula I and a ligand of a peroxisome proliferator activated receptor gamma (PPARγ):
• to inhibit at least one of the cell proliferation of the human aortic smooth muscle cells and the inflammation, wherein R1 is a first hydrogen, each of R2 to R5 is selected from a group consisting of a second hydrogen, a first hydroxide and a halogen, each of R6, R7, R9 and R10 is selected from a group consisting of a third hydrogen, a second hydroxide, a C1 to C20 alkoxy group and a benzyloxy group, and R8 is selected from a group consisting of a fourth hydrogen, a C1 to C20 alkyl group and a benzyl group.

A method for inhibiting an inflammation of a subject, comprising steps of:

• administering to the subject a first effective amount of a chalcone compound represented by formula II:
• and
• administering to the subject a second effective amount of an (RS)-5-[4-(2-[methyl(pyridin-2-yl)-amino]ethoxy)benzyl]thiazolidine-2,4-dione (rosiglitazone) to inhibit the inflammation.

A method for inhibiting a proliferation of a smooth muscle cell, comprising steps of:

• administering to the subject a first effective amount of a chalcone compound represented by formula II:
• and
• administering to the subject a second effective amount of a 2-(2-amino-3-methoxyphenyl)-chromen-4-one (PD98059) to inhibit the proliferation of the smooth muscle cell.