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US 2014/0194463 A1Published application
Compositions for treatment of cancer
AssigneeNovaRx
InventorsFeridoun KARIMI-BUSHERI, Habib FAKHRAI
Life of this patent
Estimating the term…
Abstract
Compounds that are specifically toxic to cancer stem cells are disclosed.
Claims20
A pharmaceutical composition comprising as an active ingredient at least one compound of formula (A):
- wherein:
- Het is pyrrolyl, pyrazoyl, imidazolyl, triazolyl, or tetrazolyl;
- R4 and R5 are each independently H or C1-4alkyl;
- each X is independently selected from the group consisting of halo, nitro, —OR6, —OCOR6, —COOR6, —R6NCOR6, —CONR62, —COR6, —NR62, —S(O)mR6, —CN, and R7;
- wherein R7 is C1-6alkyl, unsubstituted or substituted with halo, OR6, or NR62;
- each R6 is independently H or C1-4alkyl;
- m is 0, 1, or 2, and
- n is 0, 1, 2 or 3;
- or a tautomer thereof;
- or a pharmaceutically acceptable salt or solvate thereof.
7 more elements
A pharmaceutical composition comprising as an active ingredient at least one compound of formula (B):
- wherein:
- zero or one of A1-4 is N and the others are CH;
- R8 is —NO2, —CO2H, —PO3R9, —SO3H, or —SO2R9;
- where R9 is OH or C1-4alkyl;
- each X is independently selected from the group consisting of halo, nitro, —OR10, —OCOR10, —COOR10, —R10NCOR10, —CONR102, —COR10, —NR102, —S(O)MR10, —CN, and R11;
- Y is O or —NR10;
- R11 is C1-6alkyl, unsubstituted or substituted with halo, —OR10, or —NR102;
- n is 0, 1, 2 or 3;
- m is 0, 1, or 2;
- and
- each R10 is independently H or C1-4alkyl;
- or a pharmaceutically acceptable salt or solvate thereof.
9 more elements
Dependencies are inferred from the claim text.