US 2014/0194451 A1 · Cdc42 Inhibitor and Uses Thereof

Abstract

Compounds which inhibit the small G protein Rho GTPase cell division cycle protein Cdc42 are provided. Morphological analyses of filopodia, western blots of Ccd42 phosphorylation, and effects on cellular wound healing and on growth cone formation all demonstrate that the described compounds are able to inhibit all tested Cdc42-mediated processes. The compounds effectively inhibit, the effects of Cdc42 and effectively inhibit Cdc42-related cellular functions involving actin, such as Golgi organization and cell movement. Furthermore, the described Cdc42 inhibitor compounds may be provided as a medicament for the treatment of various conditions.

Claims16

Dependent claims

A compound of structure A:

structure B:
or a combination thereof, wherein
R1, R2, R3, R4, R5, R6, R7, R8 are each independently selected from the group consisting of fluoro, chloro, bromo, nitro, cyano, amino, methyl, hydroxylmethyl, trifluoromethyl, methoxy, trifluoromethyoxy, and ethyl;
and
A, D, E, G, J, M, W, X, Y, Z are each selected from the group consisting of nitrogen, carbon, and substituted carbon, and any of A, D, E, G, J, M, W, X, Y, Z may be missing, such that the ring structure is less than a six-membered ring.

2 more elements

Dependencies are inferred from the claim text.

Cdc42 Inhibitor and Uses Thereof

Life of this patent

Cdc42 Inhibitor and Uses Thereof

Life of this patent

Abstract

Claims16