Aminopyrimidines useful as inhibitors of protein kinases
OwnerJuan-Miguel Jimenez, Andrew Miller +5inventors
InventorsJuan-Miguel Jimenez, Andrew Miller, Jeremy Green, Huai Gao, Gregory Henkel, Michael Liu, Timothy Neuberger
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Abstract
The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Claims28
A compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- Ht is
- wherein any substitutable carbon on Ht is independently and optionally substituted with —R10;
- Ring D is a 3-10 membered heterocyclyl;
- where said heterocyclyl contains 1-2 heteroatoms selected from O, N, or S;
- and wherein the heterocyclyl is independently and optionally substituted with 1-5-R5;
- Ring D is bonded to the pyrimidine via a carbon atom;
- Z1 is N, CH, or CR10;
- RX is H, halo, or C1-6alkyl, wherein the alkyl is independently and optionally substituted with 1-5 groups selected from halo, —CN, and —OR;
- RY is H, halo, C2-6alkyl, or a 5-6 membered heterocyclyl ring containing 1-2 heteroatoms selected from O, N, or S;
- wherein said RY is independently and optionally substituted with 1-4 halo, CN, OR, or C2-6alkyl;
- each R10 is independently selected from C1-6alkyl, haloC1-6alkyl, halo, OR, C(═O)R, CO2R, COCOR, NO2, CN, S(O)R, SO2R, SR, N(R4)2, CON(R4)2, SO2N(R4)2, OC(═O)R, N(R4)COR, or N(R4)CO2R;
- each R4 is independently selected from H, C1-6alkyl, or haloC1-6alkyl;
- each R5 is independently selected from halo, haloC1-6alkyl, or C1-6alkyl;
- and
- each R is independently selected from H, C1-6alkyl, or haloC1-6alkyl.
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Dependencies are inferred from the claim text.