Detection and use of low molecular-weight modulators of the cold-menthol receptor trpm8
AssigneeBASF SE
InventorsThomas Subkowski, Claus Bollschweiler, Jens Wittenberg, Michael Krohn, Holger Zinke
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Abstract
The invention relates to novel modulators of the cold menthol receptor TRPM8, to a method for modulating the TRPM8 receptor using said modulators; to the use of the modulators for induction of cold sensation; and to objects and means produced using said modulators.
Claims16
A method for the in-vitro or in-vivo modulation of the cold menthol receptor TRMP8, comprising contacting the receptor with at least one compound which is selected from polynuclear organic compounds which, in a cellular activity test using cells which recombinantly express the human TRPM8 receptor, modulate the permeability of these cells for Ca2+ ions.
A modulator for the TRPM8 receptor which is selected from polynuclear organic compounds which, in a cellular activity test using a cell which recombinantly expresses the human TRPM8 receptor, modulates the permeability of the cell for Ca2+ ions.
Dependencies are inferred from the claim text.