Tetracyclic compounds

A compound of the Formula (E):

• or a salt thereof,
• wherein:
• R1 is H, hydroxyl, nitro, cyano, halo, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, perhaloalkyl, acyl, acyloxy, carbonylalkoxy, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, C1-C8 perhaloalkoxy, alkoxy, aryloxy, carboxyl, thiol, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl or carbonylalkylenealkoxy;
• each R2a and R2b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, hydroxyl, alkoxy, cyano, nitro or R2a and R2b are taken together with the carbon to which they are attached to form a carbonyl moiety or R2a and R2b are taken together with the carbon to which they are attached to form a cycloalkyl moiety;
• each R3a and R3b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, hydroxyl, alkoxy, cyano, nitro or R3a and R3b are taken together with the carbon to which they are attached to form a carbonyl moiety or R3a and R3b are taken together with the carbon to which they are attached to form a cycloalkyl moiety;
• each X7, X8, X9 and X10 is independently CR4;
• m and q are independently 0 or 1, provided that at least one of m and q is 1;
• each R4 is independently H, hydroxyl, nitro, cyano, halo, C1-C8 perhaloalkyl, carboxy, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, C1-C8 perhaloalkoxy, C1-C8 alkoxy, aryloxy, carboxyl, carbonylalkoxy, thiol, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aralkyl, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl, carbonylalkylenealkoxy, alkylsulfonylamino or acyl;
• each R8a, R8b, R8c, R8d, R8e and R8f is independently H, C1-C8 alkyl, carboxy, carbonylalkoxy, or is taken together with the carbon to which it is attached and a geminal R8 to form a cycloalkyl moiety or a carbonyl moiety, provided that at least one of R8a, R8b, R8c, R8d, R8e and R8f is other than H;
• each R10a and R10b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, hydroxyl, alkoxy, cyano, nitro or R10a and R10b are taken together with the carbon to which they are attached to form a carbonyl moiety or R10a and R10b are taken together with the carbon to which they are attached to form a cycloalkyl moiety;
• and
• Q is a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl or substituted or a unsubstituted heterocyclyl,
• provided that (i) the compound is other than 1-propanone, 1-(2-chloro-10H-phenothiazin-10-yl)-3-(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)-(Compound 221x) or a salt thereof, and (ii) when R1 is isopropyl and Q is substituted piperazinyl, then R8e and R8f taken together with the carbon to which they are attached do not form a carbonyl moiety.

A compound of the formula (B):

• or a salt thereof,
• wherein:
• R1 is H, hydroxyl, nitro, cyano, halo, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, perhaloalkyl, acyl, acyloxy, carbonylalkoxy, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, C1-C8 perhaloalkoxy, alkoxy, aryloxy, carboxyl, thiol, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl or carbonylalkylenealkoxy;
• each R2a and R2b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, hydroxyl, alkoxy, cyano, nitro or R2a and R2b are taken together with the carbon to which they are attached to form a carbonyl moiety;
• each R3a and R3b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, cyano or nitro or R3a and R3b are taken together with the carbon to which they are attached to form a carbonyl moiety;
• each X7, X8, X9 and X10 is CR4;
• each R4 is independently H, hydroxyl, nitro, cyano, halo, C1-C8 perhaloalkyl, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, C1-C8 perhaloalkoxy, C1-C8 alkoxy, aryloxy, carboxyl, carbonylalkoxy, thiol, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aralkyl, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl, carbonylalkylenealkoxy, alkylsulfonylamino or acyl;
• each R8c, R8d, R8e and R8f is independently H, C1-C8 alkyl, C1-C8 perhaloalkyl, carboxy, carbonylalkoxy, or is taken together with the carbon to which it is attached and a geminal R8 to form a cycloalkyl moiety or a carbonyl moiety, provided that at least one of R8c, R8d, R8e and R8f is other than H;
• each R10a and R10b is independently H, halo, a substituted or unsubstituted C1-C8 alkyl, hydroxyl, alkoxyl or R10a and R10b are taken together with the carbon to which they are attached to form a carbonyl;
• and
• Q is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl,
• provided that when R1 is isopropyl and Q is substituted piperazinyl, then R8e and R8f taken together with the carbon to which they are attached do not form a carbonyl moiety.