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US 2014/0194412 A1Published application
Thioxothiazolidine derivative having ras function inhibitory effect
AssigneesKnc Laboratories Co., Ltd., National University Corporation Kobe University
InventorsTohru Kataoka, Fumi Shima, Masahiro Neya, Daisuke Sasahara
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Abstract
The present invention provides an anticancer drug having a Ras function inhibitory action. The present invention provides a Ras function inhibitor comprising a compound represented by the formula (I′): wherein each symbol is as defined in the present specification, or a salt thereof.
Claims26
Ras function inhibitor comprising a compound represented by the formula (I′):
- wherein
- A is an optionally substituted cyclic group or an optionally substituted chain hydrocarbon group;
- B is a hydrogen atom, an optionally substituted cyclic group, an optionally substituted amino group, an optionally substituted hydroxy group or an optionally esterified or amidated carboxy group;
- X1 and X2 are each independently an oxygen atom or a sulfur atom;
- and
- Y and Z are each independently a bond or a spacer having 1 to 6 atoms,
- or a salt thereof.
4 more elements
A compound represented by the formula (I):
- wherein
- A is an optionally substituted cyclic group or an optionally substituted chain hydrocarbon group;
- B1 is a group represented by
- wherein • means a bonding site, which is an optionally substituted;
- X1 and X2 are each independently an oxygen atom or a sulfur atom;
- and
- Y and Z are each independently a bond or a spacer having 1 to 6 atoms,
- or a salt thereof.
5 more elements
A compound represented by the formula (II):
- wherein
- ring A1 and ring A2 are each independently an optionally substituted benzene ring;
- B2 is an optionally substituted cyclic group or an optionally substituted amino group;
- X1 and X2 are each independently an oxygen atom or a sulfur atom;
- Y and Z are each independently a bond or a spacer having 1 to 6 atoms;
- and
- W is an oxygen atom, a sulfur atom, or a group represented by the formula:
- —V1—(CH2)m-V2— wherein V1 and V2 are each independently a bond, an oxygen atom or a sulfur atom, and m is an integer of 1 to 3,
- or a salt thereof.
6 more elements
Dependencies are inferred from the claim text.