Benzazepines as serotonin 5-ht2c receptor ligands and uses thereof

A compound of the formula

• where
• R1 is selected from the group consisting of H, alkyl, perhaloalkyl, alkanoyl, C1-8 alkylaryl, and C1-8 alkylheteroaryl;
• R2 and R3 are independently selected from the group consisting of H, halogen, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, perhaloalkyl, CN, OR8, NR8R9, SR8, OCOR10, CONR8R9, NR8COR10, NR8CO2R10, SO2NR8R9, SO2R10, NR8SO2R10, aryl, heteroaryl, C1-8 alkylaryl, and C1-8 alkylheteroaryl;
• R4 and R5 together with the atoms which they are attached form a 5- or 6-membered carbocycle, benzofuran, dihydrobenzofuran or benzopyrane ring, substituted with one or more of each of R11a, R11b, R12a, R12b, R13a, R13b, R14a, and R14b;
• R6a and R6b are independently selected from the group consisting of H, OR8, aryl, and heteroaryl;
• or Rha and R6b taken together are —CH2CH2—;
• R7a and R7b are independently selected from the group consisting of H, OR8, aryl, and heteroaryl;
• or R7a and R7b taken together are —CH2CH2—;
• R8 is selected from the group consisting of H, C1-8alkyl, C2-8 alkenyl, C2-8 alkynyl, perhaloalkyl, C1-8 alkyl-O—C1-8 alkyl, aryl, heteroaryl, C1-8 alkyl-O-aryl, C1-8 alkyl-O-heteroaryl, C1-8 alkylaryl, and C1-8 alkylheteroaryl;
• R9 is selected from the group consisting of H, C1-8alkyl, C2-8 alkenyl, C2-8 alkynyl, perhaloalkyl, C1-8 alkyl-O—C1-8 alkyl, aryl, heteroaryl, C1-8 alkyl-O-aryl, C1-8 alkyl-O-heteroaryl, alkylaryl, and C1-8 alkylheteroaryl;
• R10 is selected from the group consisting of C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, perhaloalkyl, C1-8 alkyl-O—C1-8 alkyl, aryl, heteroaryl, C1-8 alkyl-O-aryl, C1-8 alkyl-O-heteroaryl, C1-8 alkylaryl, and C1-8 alkylheteroaryl;
• R11a and R11b are independently selected from the group consisting of H, halogen, C1-4 alkyl, perhaloalkyl, aryl, and heteroaryl;
• R12a and R12b are independently selected from the group consisting of H, halogen C1-8 alkyl, perhalo alkyl, aryl, and heteroaryl, with the proviso that when the formula is
• then R12b is not present;
• R13a and R13b are independently selected from the group consisting of H, halogen, C1-8 alkyl, perhaloalkyl, aryl, and heteroaryl;
• R14a and R14b are independently selected from the group consisting of H, halogen, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, perhaloalkyl (preferably CF3), CN, OR8, NR8R9, SRR, OCOR10, OCONR8R9, CONR8R9, NR8COR10, NR8CO2R10, NR8SO2R10, aryl, heteroaryl, C1-8 alkylaryl, and C1-8alkylheteroaryl, with the proviso that when the formula is
• then R14b is not present;
• or an isomer or a pharmaceutically acceptable salt thereof.