Multiple-component pharmaceutical formulations and methods for their use in treating neuropathology and neurodegeneration caused by traumatic injury

A method for the treatment of preventing the development of neuropathology or neurodegeneration, and for the amelioration of the effects caused by trauma to a subject, the formulation comprising two biologically active compounds in amounts that are pharmaceutically effective for each compound, respectively, when administered in combination with the other biologically active compound, the formulation comprising a pharmaceutically effective amount of the two biologically active compounds, for preventing, reducing the effects of, and reducing the risk of development of, neuropathology and neurodegeneration incident to trauma, the method comprising the steps and actions of

• A. providing a formulation adapted for the prevention of the development of neuropathology or neurodegeneration, wherein the formulation comprises two biologically active compounds in amounts that are pharmaceutically effective for each compound, respectively, when administered in combination with the other biologically active compound, the two compounds respectively comprising a pharmaceutically effective amount of:
• i. at least one biologically active compound from the group comprising anticonvulsants and antiepileptic drugs;
• and
• ii. at least one biologically active compound from the group comprising neurosteroids and neuroactive steroids;
• wherein the formulation is in a form and a dosage with respect to each of its components such that it is adapted and arranged for administration to a mammal in need thereof, and such that the development, or the risk of development, of neuropathology or neurodegeneration is reduced, lessened, attenuated or prevented, and
• B. administering the formulation to a mammal in need thereof.