Salts of Isophosphoramide Mustard and Analogs Thereof
AssigneeZIOPHARM Oncology, Inc.
InventorsJohn C. AMEDIO, JR., Barbara WALLNER, Philip B. KOMARNITSKY
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Abstract
Disclosed herein are crystalline compounds of formula (I) wherein A+ represents a hydroxylated aliphatic ammonium species; and X and Y independently represent leaving groups.
Claims30
A crystalline compound comprising IPM or an analog thereof, having a structure of formula (I)
- wherein A+ is a hydroxylated aliphatic amine or an ammonium species;
- and
- X and Y independently represent leaving groups.
(canceled)
5-6. (canceled)
(canceled)
(canceled)
12-19. (canceled)
A lyophilisate comprising IPM or an analog thereof, having a structure of formula (I)
- wherein A+ is a hydroxylated aliphatic ammonium counterion or an ammonium species;
- and
- X and Y independently represent leaving groups.
(canceled)
26-27. (canceled)
30-32. (canceled)
A pharmaceutical composition adapted for oral administration, comprising a pharmaceutically acceptable diluent or excipient and a compound of the formula
- wherein A+ represents a hydroxylated aliphatic ammonium counterion or an ammonium species;
- and
- X and Y independently represent leaving groups.
34-36. (canceled)
38-44. (canceled)
47-49. (canceled)
Dependencies are inferred from the claim text.