Anthelmintic Formulations and Treatments

A method of controlling internal parasites in ruminants and extending the time between treatments to minimize drench use, comprising treating the animal with an amount of levamisole effective to substantially eliminate the initial adult and immature parasite population present in the animal, and at substantially the same time treating the animal with an amount of macrocyclic lactones (ML) that acts for a duration of a minimum of about 3 to 5 days or more to re-program the animal's immune system to recognise incoming larvae as foreign and mount a self-treatment/immune response to the incoming larvae.

A method of controlling parasites in ruminants by treating a ruminant animal with at least (a) a long acting oral or injectable or implantable anthelmintic formulation A capable of removing or killing incoming larvae for a sufficiently long period to allow the host to recognise incoming larvae as foreign and mount an immune response/self-treatment effect to reduce the effect of the parasite including reduce egg output and incoming larvae, and (b) treating the ruminant with a short acting oral or injectable anthelmintic formulation B to substantially eliminate the initial parasite population.

An anthelmintic formulation comprising a long acting anthelmintic A together with a short acting anthelmintic B, wherein anthelmintic A is capable of a persistent activity over a period of 3 to 14 days, and wherein the short acting anthelmintic B is capable of peaking within 1-8 hours of administration and is designed to be substantially eliminated from the animal within 24-48 hours of treatment.

An injectable veterinary formulation comprising (A) a macrocyclic lactone in the range from 0.5% to 2% w/v, and (B) levamisole in the range from 5% to 60% w/v, dissolved in a non-aqueous solvent system.