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US 2014/0194359 A1Published application
Interfering rna delivery system and uses thereof
AssigneeAlcon Research, Ltd.
InventorsYing Yu, Jon E. Chatterton
Life of this patent
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Abstract
The invention provides a delivery system comprising a cell penetrating peptide, 10 histidines, and an interfering RNA molecule. The system can be used for delivering interfering RNA molecules into a cell in vivo or in vitro. Therapeutic uses for the delivery system are also provided.
Claims12
An interfering RNA delivery system comprising an interfering RNA molecule linked to a YM3-10H peptide.
A method of delivering an interfering RNA molecule into a cell, comprising:
- (a) attaching an interfering RNA molecule to a YM3-10H peptide, thereby forming an interfering RNA delivery system;
- and
- (b) administering the interfering RNA delivery system to the cell under conditions suitable for the system to enter the cell.
The method of claim 13, wherein the interfering RNA molecule is a siRNA, miRNA, or shRNA.
Dependencies are inferred from the claim text.