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US 2014/0194355 A1Published application
Isolated Nucleic Acid Molecules Encoding Variant Activin Receptor Polypeptides
AssigneeAmgen Inc.
InventorsJeonghoon Sun, Lei-Ting Tony Tam, Hui-Quan Han, Keith Soo-Nyung Kwak, Xiaolan Zhou
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Abstract
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
Claims20
An isolated protein comprising a variant activin IIB receptor polypeptide (vActRIIB) wherein said polypeptide is selected from the group consisting of:
- (a) a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 18, except for an amino acid substitution at position 28;
- (b) a polypeptide comprising the amino acid sequence set forth in amino acids 19 through 134 of SEQ ID NO:
- 18, except for an amino acid substitution at position 28;
- (c) a polypeptide comprising the amino acid sequence set forth in amino acids 23 through 134 of SEQ ID NO:
- 18, except for an amino acid substitution at position 28;
- (d) a polypeptide comprising the amino acid sequence set forth in amino acids 25 through 134 of SEQ ID NO:
- 18, except for an amino acid substitution at position 28;
- (e) a polypeptide having at least 95% identity to any one of (a) through (d), wherein the polypeptide is capable of binding myostatin, activin A, or GDF-11.
6 more elements
Dependencies are inferred from the claim text.