Methods for Treatment of Nephrotic Syndrome and Related Conditions
AssigneeThe UAB Research Foundation
InventorSumant S CHUGH
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Abstract
The present disclosure provides a method for treating and/or preventing nephrotic syndrome, such as but not limited to minimal change disease and membranous nephropathy, and conditions related to nephrotic syndrome, such as but not limited to, proteinuria and edema, as well as diabetic nephropathy, diabetes mellitus, lupus nephritis or primary glomerular disease. The present disclosure further provides methods for reducing proteinuria and other disease states as discussed herein. Such methods comprise the therapeutic delivery of an Angptl4 polypeptide or Angptl4 polypeptide derivative to a subject.
Claims37
A method for the treatment or prevention of nephrotic syndrome in a subject, said method comprising administering to the subject a pharmaceutical composition comprising an Angptl4 polypeptide derivative having decreased LPL inhibitory activity, the Angptl4 polypeptide derivative comprising the following structure:
- V—W—X—Y—Z
- wherein
- V is a sequence having at least 95% homology with SEQ ID NO:
- 23, wherein positions 39-55 are not DEMNVLAHGLLQLGQGL (positions 39-55 of SEQ ID NO:
- 1);
- W is an oligopeptide of 0-5 residues;
- X is a sequence having at least 95% homology with SEQ ID NO:
- 24;
- Y is an oligopeptide of 0-38 residues;
- and
- Z is a sequence having at least 95% homology with SEQ ID NO:
- 25.
Dependencies are inferred from the claim text.