US 2014/0194325 A1Published application

Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer

AssigneePromega Corporation

InventorsCarolyn W. Hitko, Thomas Kirkland, Thomas Machleidt, Rachel Friedman Ohana, Matt Robers, Keith Wood

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Abstract

The present invention provides compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, provided herein are bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith.

Claims22

Dependent claims

-16. (canceled)

Dependencies are inferred from the claim text.

Facts

Application: 14/104,845Filed 12 Dec 2013
Priority: 12 Dec 2012
Published: 10 Jul 2014
Term ends: Not estimatedThe source records don’t support an estimate.

Classification6 codes

G01N 33/94
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing:…
C12Q 1/66
Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; Compositions therefor; Processes of preparing such…
G01N 33/542
With immune complex formed in liquid phase: with steric inhibition or signal modification, e.g. fluorescent quenching
G01N 33/582
Involving labelled substances: with fluorescent label

Family

Application61/736,429Us provisional application · filed 12 Dec 2012
Application61/794,461Us provisional application · filed 15 Mar 2013
US 10,067,149 B2Related patent
US 2014/0194325 A1This patent

From the US filing history. Foreign family members aren’t listed.

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