Biomarkers for diagnosing alzheimer's disease
AssigneeBayer Intellectual Property GmbH
InventorsÕzkan Yalkinoglu, Gerhard König, Denis F. Hochstrasser, Jean-Charles Sanchez, Odile Carrette
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Abstract
A method for assessing the state of Alzheimer's disease in patients is disclosed. A method for monitoring the progression of Alzheimer's disease in patients is also disclosed. The method applies detection of specific peptide markers, e.g., using mass spectrometric analysis.
Claims18
(canceled)
An isolated polypeptide having the amino acid sequence of SEQ ID NO:
- 17.
A method for assessing the state of Alzheimer's disease in a subject, wherein the method comprises detecting in a sample from the subject at least one polypeptide from each of the following groups:
- a) a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:
- 7, 8, 9, 10, 11, 12, 13, 14, 15, and 16;
- b) a polypeptide having the amino acid sequence selected from the group consisting of SEQ ID NO:
- 3, 4, 5, and 6;
- and
- c) a polypeptide having the amino acid sequence of SEQ ID NO:
- 17.
A method for assessing the state of Alzheimer's disease in a subject, wherein the method comprises detecting in a sample from the subject at least three distinct polypeptides, wherein a first polypeptide is selected from the group consisting of SEQ ID NO:
- 3, 4, 5, 6, 7 and 17;
- and wherein a second polypeptide and a third polypeptide are selected from the group consisting of:
- a) a polypeptide having the amino acid sequence selected from the group consisting SEQ ID NO:
- 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17;
- b) a human cystatin C;
- c) a human beta-2-microglobulin;
- d) a 7.7 kD homologue of human myoglobin;
- e) neurosecretory protein VGF;
- f) a fragment of at least 5 amino acids of human cystatin C;
- g) a fragment of at least 5 amino acids of human beta-2-microglobulin;
- h) a fragment of at least 5 amino acids of the 7.7 kD homologue of human myoglobin;
- and
- i) a fragment of at least 5 amino acids of neurosecretory protein VGF.
Dependencies are inferred from the claim text.