Back to results
US 2014/0194305 A1Published application
Integrated multiplex target analysis
AssigneeGenMark Diagnostics, Inc.
InventorsJon Faiz KAYYEM, Jay SRINIVASAN
Life of this patent
Estimating the term…
Abstract
This invention provides biochip cartridges and instrument devices for the detection and/or analysis of target analytes from patient samples.
Claims25
A biochip cartridge comprising:
- a) a bottom substrate comprising a printed circuit board (PCB) comprising:
- i) an electrowetting grid of electrodes forming a droplet pathway comprising a plurality of electrowetting pads;
- ii) an array of detection electrodes accessible to said droplet pathway, each comprising a self-assembled monolayer and a capture probe;
- iii) a plurality of interconnections from said electrowetting grid and said detection electrodes;
- and
- b) a top plate parallel to said bottom substrate and mated thereto to form a reaction chamber.
3 more elements
A biochip cartridge comprising:
- a) a bottom substrate comprising:
- i) a printed circuit board (PCB) comprising:
- 1) an electrowetting grid of electrodes forming a droplet pathway comprising electrowetting pads, wherein at least one of said pads comprises a dried reagent;
- 2) an array of detection electrodes, each comprising a self-assembled monolayer and a capture probe, wherein said detection electrodes are accessible to said droplet pathway;
- 3) a plurality of interconnections from said electrowetting grid and said detection electrodes;
- b) a top plate parallel to said bottom substrate and mated thereto to form a reaction chamber, said top plate comprising at least one fluid hole spatially corresponding to said at least one pad comprising said dried reagent;
- c) a liquid reagent module (LRM) comprising:
- i) a plurality of blisters comprising fluid assay reagents;
- ii) a plurality of passageways in fluid connection with said blisters;
- iii) a sample inlet port in fluid connection with said reaction chamber;
- and
- d) an external housing comprising:
- i) a latched cover for sealing said sample inlet port;
- ii) a plurality of electronic connections from said interconnections.
11 more elements
An apparatus for the detection of target analytes comprising:
- a) an instrument bank comprising a plurality of biochip cartridge bays for insertion and analysis of a biochip cartridge, wherein each bay comprises:
- i) a top bay comprising actuators for a liquid reagent module (LRM);
- and
- ii) a bottom bay comprising electrical connections for an electrowetting electrode grid and detection electrodes;
- and
- b) a base station comprising:
- i) a central processing unit;
- and
- ii) a user interface comprising a touch screen display having a plurality of bay icons, each icon uniquely corresponding to one of said plurality of bays.
6 more elements
Dependencies are inferred from the claim text.