Device for washing suspended cells or particles
OwnerIvar Meyvantsson, Steve Hayes +3inventors
InventorsIvar Meyvantsson, Steve Hayes, Victoria Echeverria, Robert Lowery, Casey Lamers
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Abstract
A device and method are disclosed to enable fluid manipulations without disturbing or removing particles or cells. By engineering assay compartment geometries to take advantage of fluid mechanical effects, the flow velocity may be diminished around particles or cells. This technology may be used to process particles or cells of various kinds that are suspended in liquids or gels, and is suitable for use in high throughput screening.
Claims23
A device with patterned structures disposed to selectively diminish convective fluid flow, the device comprising:
- at least one well configured to receive particles or cells, the at least one well having a bottom with at least one portion containing patterned structures disposed to allow the particles or cells to settle out of liquid suspension onto the lowest surface within the well,
- wherein the at least one well is disposed to enable fluid delivery and removal in a volume surrounding the patterned structures and the patterned structures are disposed to diminish fluid flow at the lowest surface of the patterned structures thereby protecting the particles or cells residing thereon from fluid flow forces when fluid is delivered or removed from the volume surrounding the patterned structures.
A device for selectively diminishing convective fluid flow, the device comprising:
- at least one well configured to receive particles or cells, the at least one well having a bottom with at least one portion disposed to allow the particles or cells to settle out of liquid suspension onto a lowest surface of the well,
- wherein the at least one well is disposed to enable fluid delivery and removal in a volume surrounding the bottom portion of the well and the bottom portion is disposed to diminish fluid flow at the lowest surface thereof, thereby protecting the particles or cells residing thereon from fluid flow forces when fluid is delivered or removed from the volume surrounding the bottom of the well.
Dependencies are inferred from the claim text.