Abca1 downregulation in prostate cancer
AssigneeThe Cleveland Clinic Foundation
InventorsAngela H. Ting, Byron H. Lee
Life of this patent
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Abstract
A method of providing a prognosis or diagnosis of prostate cancer in a subject is described. The method includes obtaining a urine or prostate sample from the subject; determining the level of expression of ABCA1 in the sample; and comparing the level of expression of ABCA1 in the sample to the level of a control sample, wherein a decreased level of ABCA1 expression compared to the control indicates the subject has prostate cancer or a more severe form of prostate cancer. Methods of treating subjects identified as having prostate cancer, and kits for carrying out the method of prognosis or diagnosis are also described.
Claims20
A method of providing a prostate cancer prognosis in a subject having prostate cancer, comprising:
- (a) obtaining a urine or prostate sample from the subject;
- (b) determining the level of expression of ABCA1 in the sample;
- and
- (c) comparing the level of expression of ABCA1 in the sample to the level of a control sample, wherein a decreased level of ABCA1 expression compared to the control indicates the subject has a more severe form of prostate cancer.
A method of diagnosing prostate cancer in a subject, comprising:
- (a) obtaining a urine or prostate sample from the subject;
- (b) determining the level of expression of ABCA1 in the sample;
- and
- (c) comparing the level of expression of ABCA1 in the sample to the level of a control sample, wherein a decreased level of ABCA1 expression compared to the control indicates the subject has prostate cancer.
A kit for conducting diagnosis or prognosis of prostate cancer in a subject, comprising:
- antibody specific for the ABCA1 protein,
- a reference value or control sample for ABCA1 levels,
- reagents necessary for conducting an immunoassay, and
- a package for holding the antibody, the reference value or control sample, and the reagents.
Dependencies are inferred from the claim text.