Three-component formulations, methods and procedures, and combinations thereof, for reducing or preventing the development, or the risk of development, of neuropathology resulting from trauma

A method for the prevention of the development of neuropathology, or for the amelioration of the effects caused by trauma to a subject, the formulation comprising three biologically active compounds in amounts that are pharmaceutically effective for each compound, respectively, when administered in combination with the other two biologically active compounds, the formulation comprising a pharmaceutically effective amount of the three biologically active compounds, the method comprising the steps or actions of

• A. providing a formulation adapted for the prevention of the development of neuro-pathology, wherein the formulation comprises three biologically active compounds in amounts that are pharmaceutically effective for each compound, respectively, when administered in combination with the other two biologically active compounds, the three compounds respectively comprising a pharmaceutically effective amount of:
• i. at least one biologically active compound from the group comprising anticonvulsants and antiepileptic drugs;
• wherein the anticonvulsant or antiepileptic is at least one form of gabapentin;
• ii. at least one biologically active compound from the group comprising neurosteroids and neuroactive steroids;
• wherein the neurosteroid or neuroactive steroid is at least one form of progesterone or synthetic progestin:
• iii. at least one biologically active compound from the group comprising lithium-containing and lithium-related compounds;
• wherein the lithium-containing or lithium-related compound is at least one form of lithium carbonate:
• wherein the formulation is in a form and a dosage with respect to each of its components, such that the development, or the risk of development, of neuropathology is reduced, lessened, attenuated or prevented, and
• B. administering the formulation to a mammal in need thereof.