Clotting cascade initiating apparatus and methods of use and methods of closing wounds
AssigneeClosys Corporation
InventorKarol L. Nowakowski
Life of this patent
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Abstract
Wound closure methods and apparatuses are provided which utilize blood fluid by activating the clotting cascade of the blood fluid outside the body within a substantially enclosed sterile container then introducing coagulated blood to the wound site to complete clotting. Methods and apparatuses for providing ways of inhibiting anticoagulants and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with and/or associated with preferred procedures are also disclosed.
Claims21
A method of closing a wound in a patient, the method comprising the steps of:
- a) treating a blood fluid such that at least a portion of the blood fluid will form a clot of blood subsequent to the treatment, the blood fluid containing sufficient blood components to enable a portion of the blood fluid to clot subsequent to the treatment once a clotting cascade is initiated, the blood components being selected from the group consisting of whole blood, natural components of whole blood, whether derived from whole blood, blood extracts, or products of ex-vivo cell cultures, and procoagulating agents which assist in or enhance the clotting or coagulation of the blood fluid, the step of treating the blood fluid including initiating the clotting cascade;
- and
- b) transporting the treated blood fluid to the wound in the patient such that the blood fluid can come into contact with the patient proximate the wound and the clotting cascade can come generally to a conclusion and a clot can form proximate the wound such that a clot is formed in the wound which prevents fluid from passing through the wound.
A clotting cascade initiation apparatus within which a blood fluid can be received, the blood fluid being useful for treatment of a wound within a patient, said apparatus comprising:
- a substantially enclosed sterile containment chamber within which the blood fluid can be received and retained;
- and
- a procoagulating agent within the substantially enclosed sterile containment chamber, wherein a clotting cascade can be initiated when the blood fluid is accepted into the sterile containment chamber and exposed to the procoagulating agent, and the blood fluid can be delivered to the wound within the patient subsequent to the initiation of the clotting cascade such that the clotting cascade can be completed within the wound and a clot can form within the wound.
21-47. (canceled)
Dependencies are inferred from the claim text.