Polymer-Agent Conjugates, Particles, Compositions, and Related Methods of Use

A particle comprising:

• a) a plurality of hydrophobic polymer-therapeutic agent conjugates, wherein
• i) each hydrophobic polymer-therapeutic agent conjugate of said plurality comprises a hydrophobic polymer covalently bonded to a therapeutic agent,
• ii) said hydrophobic polymer covalently bonded to said therapeutic agent is a homopolymer or a polymer made up of more than one kind of monomeric subunit,
• iii) said hydrophobic polymer covalently bonded to said therapeutic agent has a weight average molecular weight of about 4-15 kD,
• iv) said therapeutic agent is about 1-30 weight % of said particle, and
• v) said plurality of hydrophobic polymer-therapeutic agent conjugates is about 25-80 weight % of said particle;
• b) a plurality of hydrophilic-hydrophobic polymers, wherein
• i) each of said hydrophilic-hydrophobic polymers of said plurality comprises a hydrophilic portion covalently bonded to a hydrophobic portion,
• ii) said hydrophilic portion has a weight average molecular weight of about 1-6 kD, and
• iii) said plurality of hydrophilic-hydrophobic polymers is about 5-30 weight % of said particle;
• and
• c) a surfactant, wherein said surfactant is about 15-35 weight % of said particle.