Surface binding of nanoparticle based drug delivery to tissue
AssigneeMassachusetts Institute of Technology
InventorsAmbika Goel Bajpayee, Alan Grodzinsky, Cliff Richard Wong, Moungi G. Bawendi
Life of this patent
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Abstract
Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as osteoarthritis and injury.
Claims38
A method for delivering an active agent to a connective tissue in a subject, comprising:
- administering to a subject, a microparticle having an average particle size of greater than 10 nm, wherein the microparticle is functionalized with a connective tissue binding compound and includes a first active agent, wherein the active agent is delivered to the connective tissue as it is released from the microparticle, wherein the active agent is a therapeutic agent for the treatment of musculoskeletal disease or injury.
2-3. (canceled)
5-6. (canceled)
8-23. (canceled)
A composition comprising:
- a microparticle having an average particle size of greater than 10 nm, wherein the microparticle is functionalized with a connective tissue binding compound and includes a first active agent, and a nanoparticle having an average particle size of 10 nm or less, wherein the nanoparticle includes a second active agent.
29-54. (canceled)
A method for delivering an active agent to a connective tissue in a subject, comprising:
- administering to a subject, nanoparticle having an average particle size of 10 nm or less, wherein the nanoparticle comprises a polymer having a net positive charge of greater than 6, wherein the nanoparticle is functionalized with an active agent.
(canceled)
A composition comprising:
- a nanoparticle having an average particle size of 10 nm or less, wherein the nanoparticle includes an active agent, wherein the active agent is a therapeutic agent for the treatment of disease condition of a bone or connective tissue and wherein the nanoparticle comprises a polymer having a net positive charge of greater than 6.
A composition comprising:
- a nanoparticle of avidin or a fragment thereof and a therapeutic agent selected from the group consisting of a Disease Modifying Osteoarthritis Drug (DMOAD), a pro-anabolic growth factors and an anti-catabolic agent.
80-86. (canceled)
Dependencies are inferred from the claim text.