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US 2014/0193492 A1Published application
Method for the preparation of a pharmaceutical composition comprising 5-aminosalicylic acid for use in treatment of ulcerative colitis and crohn's disease
AssigneeFerring B.V.
InventorSvenn Kluver Jepsen
Life of this patent
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Abstract
The present invention concerns a new method of preparing granules comprising 5-aminosalicylic acid and a new method of preparing a pharmaceutical composition for the treatment of ulcerative colitis or Crohn's disease by oral administration comprising as active ingredient 5-aminosalicylic acid.
Claims17
1-27. (canceled)
A composition comprising dry extruded strong, smooth non-spherical granules comprising 5-aminosalicylic acid (5-ASA) and a pharmaceutically acceptable binder, wherein:
- the weight ratio of the binder to 5-ASA in the granules is up to 6.5:100 and
- the granules are made by a process comprising extruding a wet mass comprising the binder, 5-ASA, and a solvent comprised of at least 50% w/w water through an extruder.
Dependencies are inferred from the claim text.