In Situ Antigen-Generating Cancer Vaccine

A biopsy-free method for producing a processed tumor antigen in situ comprising administering to a subject diagnosed with a cancer a porous 3-dimensional scaffold, said scaffold comprising a chemoattractant of cancer cells, maintaining said scaffold in situ for a time period sufficient to accumulate a circulating cancer cell to yield a cancer cell-containing scaffold, and contacting said cell-containing scaffold with a cytotoxic or cytolytic element to produce a processed tumor antigen.