Compositions and methods for treating centrally mediated nausea and vomiting
AssigneeHelsinn Healthcare SA
InventorsFabio TRENTO, Sergio CANTOREGGI, Giorgia ROSSI, Roberta CANNELLA, Daniele BONADEO
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Abstract
Provided are compositions and methods for treating or preventing nausea and vomiting in patients undergoing chemotherapy, radiotherapy, or surgery.
Claims12
1-51. (canceled)
An oral pharmaceutical dosage form comprising about 0.56 mg of palonosetron hydrochloride and about 300 mg of netupitant as the free base.
An oral pharmaceutical dosage form in the form of a capsule comprising a hard outer shell, three tablets comprising about 100 mg of netupitant each, and one soft-gel capsule comprising about 0.56 mg of palonosetron hydrochloride, wherein the tablets and soft-gel capsule are housed within the hard outer shell.
A dosage form formulated for oral administration comprising a therapeutically effective amount of a) netupitant and b) palonosetron, wherein a single dose of the composition provides a median tmax of netupitant that is about 0.5 hours shorter than is provided by a single dose of a composition having the same amount of netupitant alone.
A pharmaceutical composition formulated for oral administration comprising a therapeutically effective amount of a) netupitant and b) palonosetron, wherein a single dose of the composition provides a greater area under the curve (AUC) of netupitant than is provided by a single dose of a composition having the same amount of netupitant alone.
Dependencies are inferred from the claim text.