Influenza virus immunogenic compositions and uses thereof
OwnerSylvie Carine Bertholet Girardin, Andrew Geallinventors
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Abstract
Immunogenic compositions comprise a RNA component and a polypeptide component. The RNA component is a self-replicating RNA. The polypeptide component comprises an epitope from an influenza virus antigen (the first epitope), and the RNA component encodes a polypeptide which also comprises an epitope from an influenza virus antigen (the second epitope). Delivery of epitopes in these two different manners can enhance the immune response to influenza virus as compared to immunization with the RNA or the polypeptide alone.
Claims17
An immunogenic composition comprising:
- (i) a self-replicating RNA molecule that encodes a first polypeptide antigen comprising a first epitope from an influenza virus antigen;
- and (ii) a second polypeptide antigen comprising a second epitope from an influenza virus antigen;
- wherein:
- (a) the first and second epitopes are both from influenza hemagglutinin;
- (b) the first and second epitopes are both from influenza A virus;
- and/or
- (c) the first epitope and the second epitope are both from influenza B virus.
A kit comprising (a) a first kit component comprising a polypeptide that comprises an epitope from an influenza virus antigen, and (b) a second kit component comprising a self-replicating RNA which encodes a polypeptide that comprises an epitope from an influenza virus antigen.
Dependencies are inferred from the claim text.