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US 2014/0193482 A1Published application
Modified polynucleotides encoding v-myc avian myelocytomatosis viral oncogene homolog
AssigneeModerna Therapeutics, Inc.
InventorsStephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Susan Whoriskey, Ron Weiss
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Abstract
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Claims24
A method of producing a protein of interest in a cell, tissue or organism comprising contacting said cell, tissue or organism with a nucleic acid encoding SEQ ID NO:
- 1388, wherein said nucleic acid comprises a coding region, said coding region having an altered G/C content as compared to the G/C content of the coding region comprising nucleotides 511-1875 of SEQ ID NO:
- 764.
A nucleic acid encoding SEQ ID NO:
- 1388, wherein said nucleic acid comprises a coding region, said coding region having an altered G/C content as compared to the G/C content of the coding region comprising nucleotides 511-1875 of SEQ ID NO:
- 764.
Dependencies are inferred from the claim text.