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US 2014/0193473 A1Published application
Materials and methods for controlling vasculogenesis from endothelial colony forming cells
AssigneeIndiana University Research and Technology Corporation
InventorsMervin C. Yoder, Paul Critser, Sherry Voytik-Harbin
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Abstract
Materials and methods are disclosed for controlling vasculogenesis using building blocks of a collagen matrix and endothelial colony forming cells (ECFC). The building blocks may be isolated by fractionating an acid soluble Type I collagen. The building blocks comprising monomers and/or oligomers may be recombined in desired ratios to alter the matrix microenvironment and to influence ECFC behavior.
Claims20
A vessel forming matrix comprising:
- a population of endothelial colony forming cells in a polymerized matrix comprising at least one fraction of an acid soluble Type I collagen.
A method of promoting vessel formation comprising the steps of:
- obtaining an engineered collagen matrix from an oligomer-rich fraction of a Type I acid soluble collagen;
- and
- seeding the matrix with a plurality of endothelial colony forming cells to form one or more vessels within the matrix.
Dependencies are inferred from the claim text.