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US 2014/0193466 A1Published application
Silk compositions and methods of using same
AssigneeCornell University
InventorsBrian D Lawrence, Alejandro Navas, Mark I. Rosenblatt
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AssigneeCornell University
InventorsBrian D Lawrence, Alejandro Navas, Mark I. Rosenblatt
Estimating the term…
The present invention provides for silk-derived compositions for treating a wide variety of ocular conditions. The composition is produced by processing the silk cocoon into a water-based solution (i.e., a dissolved silk), which is then cast into a film. The film may be transparent to visible light, and curved in shape for easy application to the ocular surface. The silk film may either self-adhere or be sutured to cover the wound. The degradation time of the film may range from 1 minute to 24 hours, or from 2 hours to 20 hours. The present compositions can help regenerate damaged corneal tissue, thus promoting healing.
A degradable composition comprising fibroin, wherein fibroin comprises β-sheet conformation ranging from about 0% to about 30%, and wherein, upon contacting with a body fluid, less than about 20% (w/w) of the composition degrades after about 1 minute, and greater than about 80% (w/w) of the composition degrades after about 24 hours.
A degradable composition comprising fibroin, wherein the composition comprises about 1% (w/w) to about 12% (w/w) water, and wherein, upon contacting with a body fluid, less than about 20% (w/w) of the composition degrades after about 1 minute, and greater than about 80% (w/w) of the composition degrades after about 24 hours.
A degradable composition comprising fibroin, wherein the composition comprises about 1% (w/w) to about 12% (w/w) water, wherein fibroin comprises β-sheet conformation ranging from about 0% to about 30%, and wherein, upon contacting with a body fluid, less than about 20% (w/w) of the composition degrades after about 1 minute, and greater than about 80% (w/w) of the composition degrades after about 24 hours.
A method for treating an ocular condition in a subject comprising applying a degradable composition to an eye of the subject, wherein the composition comprises fibroin, wherein fibroin comprises β-sheet conformation ranging from about 0% to about 30%, and wherein, upon contacting with the eye, less than about 20% (w/w) of the composition degrades after about 1 minute, and greater than about 80% (w/w) of the composition degrades after about 24 hours.
Dependencies are inferred from the claim text.