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AssigneeThe Regents of the University of Michigan
InventorsJames R. Baker, JR., Paul E. Makidon, Whitney A. Dunlap, Jessica A. Knowlton, Benjamin Swanson
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The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides immunogenic nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against a bacterial species of the genus Streptococcus (e.g., Streptococcus pneumoniae))). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
An immunogenic composition comprising a nanoemulsion and an immunogen, wherein said nanoemulsion comprises a non-ionic surfactant, ethanol, cetylpyridinium chloride (CPC), oil and water, and wherein said immunogen comprises killed whole cell Streptococcus pneumoniae.
An immunogenic composition comprising a nanoemulsion and a Streptococcus pneumoniae immunogen, wherein said nanoemulsion comprises a non-ionic surfactant, ethanol, cetylpyridinium chloride (CPC), oil and water.
Dependencies are inferred from the claim text.