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US 2014/0193460 A1Published application
Herpes virus vaccine and methods of use
AssigneeThe Regents of the University of California
InventorsDeborah H. Spector, Christopher S. Morello, Kimberly A. Kraynyak
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Abstract
Provided herein are, inter alia, vaccines and methods of using the same for the treatment or prevention of Herpesvirus infections.
Claims33
A Herpesvirus (HV) vaccine comprising inactivated HV, a lipopolysaccharide (LPS)-derived adjuvant and an aluminum-based mineral salt adjuvant.
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A method of preparing a Herpesvirus (HV) vaccine, said method comprising:
- (i) contacting an HV-cell mixture with a sulfated or sulfonated polysaccharide, wherein said HV-cell mixture comprises HV particles, cells and portions of cells;
- (ii) separating said HV particles from said cells thereby forming isolated HV particles;
- (iii) inactivating said isolated HV particles thereby forming inactivated HV particles;
- (iv) combining said inactivated HV particles with a lipopolysaccharide-derived adjuvant and an aluminum-based mineral salt adjuvant thereby forming an HV vaccine.
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Dependencies are inferred from the claim text.