Peptide carrier fusion proteins as allergy vaccines
AssigneeBiomay AG
InventorsKatarzyna Niespodziana, Margarete Focke-Tejkl, Susanne Vrtala, Srinita Banerjee, Kuan-Wei Chen, Milena Weber, Rudolf Valenta, Katharina Marth
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Abstract
The present invention relates to a polypeptide comprising at least three peptide fragments consisting of 10 to 50 consecutive amino acid residues of at least one wild-type allergen fused to the N- and C-terminus of a surface polypeptide of a virus of the hepadnaviridae family or at least one fragment of said surface polypeptide.
Claims27
A polypeptide comprising at least four peptide fragments consisting of 20 to 50 consecutive amino acid residues of a wild-type allergen fused to the N- and C-terminus of a surface polypeptide of a virus of a hepadnaviridae family or a fragment of the surface polypeptide.
13-16. (canceled)
19-20. (canceled)
A vaccine formulation comprising a mixture of hypoallergenic polypeptides derived from grass pollen allergens, wherein the polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID No. 14, SEQ ID No. 15, Seq ID No. 16, and SEQ ID No. 17.
A vaccine formulation comprising a mixture of hypoallergenic polypeptides derived from birch pollen allergens, wherein the polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO. 18 AND SEQ ID NO. 19.
25-27. (canceled)
A method of treating or preventing an allergy in a human or an animal, comprising administering a polypeptide comprising at least four peptide fragments consisting of 20 to 50 consecutive amino acid residues of a wild-type allergen fused to a N- and C-terminus of a surface polypeptide of a virus of a hepadnaviridae family or a fragment of the surface polypeptide.
A method of treating or preventing an allergy in a human or an animal, comprising administering a mixture of more than one hypoallergenic polypeptide, wherein the polypeptide comprises at least four peptide fragments consisting of 20 to 50 consecutive amino acid residues of a wild-type allergen fused to a N- and C-terminus of a surface polypeptide of a virus of a hepadnaviridae family or a fragment of the surface polypeptide.
Dependencies are inferred from the claim text.