Compositions and methods for cancer treatment
AssigneeUniversity Health Network
InventorsJeffrey A. Medin, Andrea McCart, Severine Loisel-Meyer
Life of this patent
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Abstract
Compositions and methods for delivering tumor associated antigens and immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as colon cancer.
Claims41
A composition, vector construct or virus comprising:
- a stably integrating delivery vector;
- a tumor associated antigen cassette;
- a lysomal targeting cassette;
- wherein the lysosomal targeting cassette is operatively linked to the tumor associated antigen cassette.
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The composition, vector construct or virus of claim 20, wherein the IL-12 polynucleotide is a mammalian IL-12 polynucleotide, or wherein the IL-12 polynucleotide comprises at least 70% sequence identity to sequences having SEQ ID NO:16-19.
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Dependencies are inferred from the claim text.