Vaccines and immunotherapeutics comprising il-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same
AssigneeThe Trustees of the University of Pennsylvania
InventorsDAVID B. WEINER, KIMBERLY A. KRAYNYAK, MICHELE KUTZLER
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Abstract
Compositions, recombinant vaccines and live alternated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-15Ra or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
Claims20
A composition comprising:
- an isolated nucleic acid molecule that encodes an immunogen;
- and an isolated nucleic acid molecule that encodes IL-15Rα or functional fragments thereof.
A recombinant vaccine comprising a nucleotide sequence that encodes an immunogen operably linked to regulatory elements, and a nucleotide sequence that encodes IL-15Rα or a functional fragment thereof.
A live attenuated pathogen comprising a nucleotide sequence that encodes IL-15Rα or a functional fragment thereof.
A nucleic acid molecule comprising SEQ ID NO:
- 1 or a fragment thereof that has IL-15Rα immunomodulatory function, IL-15 binding function, binding function to other subunits of a IL-15 receptor complex, or a combination thereof.
Dependencies are inferred from the claim text.