Extracellular targeted drug conjugates
AssigneeCentrose, LLC
InventorJames R. Prudent
Life of this patent
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Abstract
Extracellular-targeted drug conjugates (EDC) in which a targeting moiety targeting a protein associated with the Na,K-ATPase is linked to a drug that interacts with the Na,K-ATPase through a linker a stable linker are useful in the treatment of disease and as tools for the evaluation of biological systems.
Claims16
1-26. (canceled)
An extracellular-targeted drug conjugate (EDC) comprising a targeting moiety linked by a non-cleavable linker to a therapeutic agent, wherein the targeting moiety is selected from the group consisting of an antibody, epitope binding peptide, and aptamer and binds to an extracellular target that is not a Na,K-ATPase, and wherein the therapeutic agent acts on the Na,K-ATPase.
Dependencies are inferred from the claim text.