Methods and compositions for treating and diagnosing diseases

An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:

• a) SEQ ID NOS:5-8, 10, 13-15, 20-23, 37-50, 60-68, 75-80, 86-90, 103-114, 117-118, 122-126, 135-143, 146-147, 150-151, 160-167, 175-181, 184-185;
• b) nucleotide sequences that encode a CAT protein comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:1-4, 9, 11-12, 16-19, 24-36, 51-59, 69-74, 81-85, 91-102, 115-116, 119-121, 127-134, 144-145, 148-149, 152-159, 168-174, and 182-183;
• and
• c) nucleotide sequences that are completely complementary to the nucleotide sequences of a) or b).

A method of diagnosing, prognosing, or determining risk of cancer in a subject, the method comprising detecting at least one molecule in a sample, wherein the presence or abundance of the molecule is indicative of cancer, and wherein the molecule is selected from the group consisting of:

• a) CAT proteins comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:1-4, 9, 11-12, 16-19, 24-36, 51-59, 69-74, 81-85, 91-102, 115-116, 119-121, 127-134, 144-145, 148-149, 152-159, 168-174, and 182-183;
• b) antibodies that selectively bind to the CAT protein of a);
• c) nucleic acid molecules comprising a nucleotide sequence selected from the group consisting of SEQ ID NOS:5-8, 10, 13-15, 20-23, 37-50, 60-68, 75-80, 86-90, 103-114, 117-118, 122-126, 135-143, 146-147, 150-151, 160-167, 175-181, 184-185 and nucleotide sequences that encode the CAT protein of a);
• and
• d) nucleic acid molecules comprising a nucleotide sequence that is completely complementary to the nucleic acid molecule of c).