Anti-human epo receptor antibodies and methods of use
AssigneeHoffmann-La Roche Inc.
InventorsMichael Jarsch, Olaf Mundigl
Life of this patent
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Abstract
Herein is reported an antibody that specifically binds to human EPO receptor, wherein the antibody binds to EPO receptor fragment LPGPGGSVDIV (SEQ ID NO: 01) but that does not specifically bind to a protein obtainable from human endothelial cells that has a molecular weight of about 66 kD.
Claims20
A method for detecting in vitro human EPO receptor comprising the following step
- determining in vitro the presence of human EPO receptor in a sample by incubating the sample with an EPO receptor antibody that specifically binds to human EPO receptor fragment LPGPGGSVDIV (SEQ ID NO:
- 01) and thereby detecting in vitro human EPO receptor,
- wherein the EPO receptor antibody that specifically binds to EPO receptor fragment LPGPGGSVDIV (SEQ ID NO:
- 01) does not specifically bind to a protein obtainable from human endothelial cells that has a molecular weight of about 66 kD.
An antibody that specifically binds to human EPO receptor, characterized in that the antibody binds to human EPO receptor fragment LPGPGGSVDIV (SEQ ID NO:
- 01) and does not specifically bind to a protein obtainable from human endothelial cells that has a molecular weight of about 66 kD.
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A method for producing an antibody that specifically binds to human EPO receptor comprising the following steps:
- immunizing an animal with a polypeptide comprising the EPO receptor fragment LDKWLLPRNPPSEDLPGPGGSVDIV (SEQ ID NO:
- 02), and
- selecting an antibody specifically binding to the EPO receptor fragment LPGPGGSVDIV (SEQ ID NO:
- 01) and thereby producing an antibody that specifically binds to human EPO receptor.
Dependencies are inferred from the claim text.