Anti-her antibodies
AssigneeGenentech, Inc.
InventorsGermaine Fuh, Lauric Haber, Gabriele Schaefer, Mark X. Sliwkowski
Life of this patent
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Abstract
The invention provides anti-HER antibodies, including multispecific anti-HER antibodies, compositions comprising and methods of using these antibodies. Also provided herein are EGFR/HER3 multispecific antibodies that are less toxic than traditional EGFR antagonists.
Claims29
A multispecific antibody comprising an antigen-binding domain that specifically binds to EGFR and HER3, wherein the toxicity of the antibody is less than the toxicity of an EGFR antagonist.
A multispecific antibody comprising a heavy chain variable domain sequence of SEQ ID NO:
- 30 and a light chain variable domain sequence of SEQ ID NO:
- 29.
A multispecific antibody comprising an antigen-binding domain that specifically binds to EGFR and HER3, wherein the antibody comprises
- (a) HVR-H1 comprising the amino acid sequence of LSGDWIH (SEQ ID NO:
- 48);
- (b) HVR-H2 comprising the amino acid sequence of VGEISAAGGYTD (SEQ ID NO:
- 51);
- and
- (c) HVR-H3 comprising the amino acid sequence of ARESRVSFEAAMDY (SEQ ID NO:
- 53);
- and
- (d) HVR-L1 comprising the amino acid sequence of NIATDVA (SEQ ID NO:
- 55);
- (e) HVR-L2 comprising the amino acid sequence of SASF (SEQ ID NO:
- 56);
- and
- (f) HVR-L3 comprising the amino acid sequence of SEPEPYT (SEQ ID NO:
- 57).
A multispecific antibody comprising an antigen-binding domain that specifically binds to EGFR and HER3, wherein the antibody comprises
- (a) a heavy chain variable domain having at least 95% sequence identity to the amino acid sequence of SEQ ID NO:
- 30;
- (b) a light chain variable domain having at least 95% sequence identity to the amino acid sequence of SEQ ID NO:
- 29;
- or
- (c) a heavy chain variable domain as in (a) and a light chain variable domain as in (b).
Dependencies are inferred from the claim text.