Multimeric constructs

A method of inhibiting VEGF activity in a cell comprising delivering to the cell a nucleic acid molecule that encodes a fusion protein of the formula X-Y-Z, wherein

• X comprises the Ig-like domain 2 of VEGF-R1 but lacks the Ig-like domains 1 and 3 of a VEGF receptor, with said Ig-like domain 2 of VEGF-R1 being covalently linked to moiety Z via moiety Y;
• Y is selected from the group consisting of gly9 (SEQ ID NO:
• 27), glu9 (SEQ ID NO:
• 28), ser9 (SEQ ID NO:
• 29), gly5-cys-pro2-cys (SEQ ID NO:
• 30), (gly4ser)3 (SEQ ID NO:
• 31), Ser-Cys-Val-Pro-Leu-Met-Arg-Cys-Gly-Gly-Cys-Cys-Asn (SEQ ID NO:
• 32), Pro-Ser-Cys-Val-Pro-Leu-Met-Arg-Cys-Gly-Gly-Cys-Cys-Asn (SEQ ID NO:
• 13), Gly-Asp-Leu-Ile-Tyr-Arg-Asn-Gln-Lys (SEQ ID NO:
• 26), and Gly9-Pro-Ser-Cys-Val-Pro-Leu-Met-Arg-Cys-Gly-Gly-Cys-Cys-Asn (SEQ ID NO:
• 34), and
• Z is a CH3 region of an IgG heavy chain molecule or an Fc portion of an antibody molecule,
• whereby an effective amount of said fusion protein is expressed in the cell thereby inhibiting VEGF activity.