Humanized anti-cd40 antibodies
AssigneesSeattle Genetics, Inc., Genentech, Inc.
InventorsLeonard G. Presta, Lori Y. O'Connell, Svetlana O. Doronina
Life of this patent
Estimating the term…
Abstract
Provided are humanized anti-CD40 antibodies and antigen-binding fragments and methods for treating disease characterized by expression of CD40 antigen.
Claims49
An isolated antibody or antigen-binding fragment that specifically binds to human CD40, comprising a humanized heavy chain variable domain comprising a framework region having an amino acid sequence at least 90% identical to the amino acid sequence of the framework region of the human variable domain heavy chain subgroup III concensus amino acid sequence of SEQ ID NO:2, and comprising at least one CDR having an amino acid sequence at least 90% identical to a corresponding heavy chain CDR of SEQ ID NO:3.
An isolated antibody or antigen-binding fragment that specifically binds to human CD40, comprising a humanized light chain variable domain comprising a framework region having an amino acid sequence at least 90% identical to the framework region of the human variable domain light chain subgroup kappa I concensus amino acid sequence of SEQ ID NO:13, and comprising at least one CDR having an amino acid sequence at least 90% identical to a corresponding light chain CDR of SEQ ID NO:14.
Dependencies are inferred from the claim text.