Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
AssigneeUnited Therapeutics Corporation
InventorsRoger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
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Abstract
Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.
Claims20
A method for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a composition comprising a mesenchymal stem cell (MSC) or a part of a culture medium that has been in contact with the MSC and contains one or more components of the MSC.
A pharmaceutical composition comprising a therapeutically effective amount of a prostacyclin and a composition comprising a mesenchymal stem cell (MSC) or a part of a culture medium that has been in contact with the MSC and contains one or more components of the MSC and a pharmaceutically acceptable carrier.
A method for preparing a composition comprising a mesenchymal stem cell (MSC) or a culture medium that has been in contact with the MSC and contains one or more components of the MSC for in vivo delivery, comprising contacting the MSC with a prostacyclin.
Dependencies are inferred from the claim text.