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AssigneeHoward Florey Institute
InventorsTrevor Kilpatrick, Michele Denise Binder, Zhi-Ming Gerry Ma
Estimating the term…
The present disclosure relates to the use of TAM receptor ligands, metabolites, precursor and binding partners thereof in the field of inflammatory neuropathology. This includes the early diagnosis and monitoring of an inflammatory neuropathology as well as screening for medicaments used in the treatment and prophylaxis of such a condition. The method comprises screening blood fluid from a subject for a TAM receptor ligand, or metabolite, or precursor thereof wherein an altered level of the ligand or its metabolite or precursor relative to a control is indicative of the presence of an inflammatory neuropathological disease or condition or a likelihood of developing the same. Diagnostic kits, high throughput screening assays and therapeutic compositions for inflammatory neuropathies are also taught herein.
A method for detecting the presence of an inflammatory neuropathological disease or condition in a subject, said method comprising screening blood plasma or other suitable blood fluid from said subject for a TAM receptor ligand or metabolite or precursor thereof wherein an altered level of the ligand or its metabolite or precursor relative to a control is indicative of the presence of an inflammatory neuropathological disease or condition or a likelihood of developing same.
13-23. (canceled)
The method of claim 31, wherein a level of the ligand or metabolite or precursor thereof greater than 105% of the level in a control is indicative of the presence of the inflammatory neuropathological disease or condition or a likelihood of developing same.
The method of claim 31, wherein a level of the ligand or metabolite or precursor thereof 20% to 95% of the levels in a control is indicative of the presence of the inflammatory neuropathological disease or condition or a likelihood of developing same.
A method for monitoring progression of an inflammatory neuropathological disease or condition in a subject, the method comprising screening blood plasma or other suitable blood fluid in said subject for a TAM receptor ligand or a metabolite or precursor thereof over time wherein a change in levels of ligand within a time period is indicative of disease progression.
A method for detecting the presence of an inflammatory neuropathological condition or disease or monitoring its progression in a subject, the method comprising screening blood plasma or other suitable blood fluid from said subject for levels of a TAM receptor ligand or a metabolite or precursor thereof, wherein an elevated level of the ligand or a metabolite or precursor thereof compared to a control is indicative of the presence of an inflammatory neuropathological disease or condition or a likelihood of developing same or the continued progression of the disease or condition.
A method of treating, controlling or preventing development of an inflammatory neuropathological disease or condition, the method comprising measuring the level of a TAM receptor ligand in a subject and comparing the level to a control, the control being a level from a normal, healthy subject or population of subjects or a level from the same subject as being treated taken at an earlier time point, and if the level of the TAM receptor ligand is altered compared to the control administering to the subject an effective amount of an agent selected from the group consisting of:
Dependencies are inferred from the claim text.