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US 2014/0193362 A1Published application
Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection
AssigneeGlobeImmune, Inc.
InventorsThomas H. King, David Apellan
Life of this patent
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Abstract
Disclosed are immunotherapeutic compositions and methods for preventing and/or treating hepatitis delta virus (HDV) infection, including yeast-based HDV immunotherapeutic compositions and methods of use of such compositions to prevent and/or treat HDV infection and symptoms and sequela thereof.
Claims38
An immunotherapeutic composition comprising:
- a) a yeast vehicle;
- and
- b) a fusion protein comprising HDV antigens, wherein the HDV antigens consist of at least one immunogenic domain of an HDV large antigen (HDAg-L) or HDV small antigen (HDAg-S), wherein the nuclear localization sequence (NLS) has been inactivated by substitution or deletion of one or more amino acids of the NLS;
- wherein the composition elicits an HDV-specific immune response when administered to a subject.
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An immunotherapeutic composition comprising:
- a) a yeast vehicle;
- and
- b) a fusion protein comprising HDV antigens, wherein the HDV antigens consist of at least one immunogenic domain of an HDV large antigen (HDAg-L) or HDV small antigen (HDAg-S), wherein the HDV antigen is less than a full-length HDAg-L or HDAg-S protein;
- wherein the composition elicits an HDV-specific immune response when administered to a subject.
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Dependencies are inferred from the claim text.