Back to results
US 2014/0193358 A1Published application
Treating cancer stem cells using targeted cargo proteins
AssigneeProtox Therapeutics, Inc.
InventorFahar Merchant
Life of this patent
Estimating the term…
Abstract
The disclosure provides targeted cargo proteins that are useful for targeting cancer stem cells, and methods of their use in treating cancer.
Claims28
A method of treating a cancer stem cell in a subject, comprising:
- administering to the subject a targeted cargo protein, wherein the targeted cargo protein comprises:
- (a) one or more cargo moieties;
- and
- (b) one or more targeting moieties that bind to a target displayed by a cancer stem cell, wherein the targeting moiety is derived from a natural ligand to the target, thereby treating the cancer stem cell in the subject.
1 more element
A method of treating a cancer stem cell in a subject, comprising:
- administering to the subject a targeted cargo protein, wherein the targeted cargo protein comprises:
- (a) one or more cargo moieties selected from aerolysin, proaerolysin, bouganin, ricin, Pseudomonas exotoxin, cholera toxin, diphtheria toxin, and BAD;
- and
- (b) one or more targeting moieties that bind to a target displayed by a cancer stem cell, thereby treating the cancer stem cell in the subject.
1 more element
Dependencies are inferred from the claim text.