Imaging contrast agents and uses thereof
AssigneeThe Research Foundation of State University of New York
InventorsJanet R. Morrow, Pavel Tsitovich, Sarina Dorazio, Abiola Olatunde
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Abstract
Provided are macrocyclic compounds having a macrocyclic core which has at least one macrocyclic donor and at least one pendant group which has at least one donor group. The macrocyclic compounds can be complexed to Fe(II) and Ni(II). The macrocyclic compounds can be used in imaging methods. For example, the compounds can be used MRI paraCEST contrast agents.
Claims12
A macrocyclic compound having a macrocyclic core comprising from 9 to 15 atoms, wherein at least one of the atoms in the macrocyclic core is a N atom, at least two carbon atoms separate a heteroatom selected from the group consisting of:
- N atom, O atom, or S atom, and one or more of the following pendant groups as substituents on the macrocyclic core:
- wherein each R4 is independently selected from H, C1 to C12 alkyl groups, PEG groups, thioether groups, or CH2CO2R8, each R5 is independently selected from H, C1 to C12 alkyl groups, PEG groups, thioether groups, CH2CO2R8, or OCH3, R6 is H or OCH3, R7 is H, OCH3, or CO2H, and each R8 and R9 is independently selected from H, C1 to C12 alkyl groups, PEG groups, thioether groups, the macrocyclic compound has at least one exchangeable proton, and a Fe(II) or Ni(II) cation is complexed to the macrocyclic core and/or at least one pendant group substituent of the macrocyclic compound.
Dependencies are inferred from the claim text.