New family of analogues and nadp+ or nadph, their preparation and their application in therapeutics

Compounds of formula I:

• wherein:
• (i) X represents an electron acceptor group, chosen from the group comprising:
• —NO2,
• —CN,
• —CHO,
• —COOH,
• —CF3,
• —F,
• —CH═C(CN)2,
• —SO3H,
• —CONR9R10 or SO2NR9R10, in which R9 and R10 represent each independently of each other an hydrogen, a linear or branched (C1-C3) alkyl group, or an aryl group,
• —COR9, in which R9 represents an hydrogen, a linear or branched (C1-C3) alkyl group, or an aryl group, or
• a tetrazolyl group,
• (ii) Y represents an electron donor group, chosen from the group comprising —NR19—, —OC(R19R14)—, or —SC(R19R14)—, in which:
• —R19 is chosen from:
• a hydrogen,
• a linear (C1-C8) alkyl group, in particular an ethyl, said alkyl group being optionally substituted by one or more group selected from:
• —OH group, —NH2 group, —COOH group, CONH-arylCOOH group or NHCOarylCOOH group or NHCOarylsulfate group, or NHCOarylsulfonate group, wherein the aryl group is chosen from phenyl, naphtyl or biphenyl, or
• a hydrosoluble organic group, in particular PEG,
• —R14 represents a hydrogen or a linear or branched (C1-C4) alkyl group, optionally substituted by —OH.
• (iii) A represents a bond chosen from the group comprising:
• (a) —C≡C—, or
• wherein:
• M1 and M2 represent independently of each other H, F, Cl, Br or I,
• n is an integer chosen from 1, 2, or 3,
• (iv) R1, R2, R3, R4, R5, R6, R7 or R8 are each independently selected from the group comprising:
• —H,
• —F, Cl, Br, I,
• a linear or branched (C1-C4) alkyl, optionally substituted by one or more substituants chosen from:
• —OH,
• —NR11R12, in which R11 and R12 represent each independently of each other an hydrogen or a linear or branched (C1-C3) alkyl group, or
• —COOR11, in which R11 represents hydrogen or a linear or branched (C1-C3) alkyl group,
• —CONHR13 or NHCOR13, in which R13 represents a linear or branched (C1-C4) alkyl group,
• (v) L represents a spacer group selected from the group comprising:
• wherein m and q represent each independently of each other an integer chosen from 0 to 5, said groups being optionally substituted by one or more OH,
• (vi) B represents the following formula II:
• wherein:
• T represents an oxygen atom, or a sulphur atom, preferably an oxygen atom;
• —R16 and R17 represent each independently of each other OH, H2PO4, HSO4, 0PO3(NH4)2, or any salt of these phosphate or sulphate groups
• —R18 represents a purine-base or a pyrimidine-base, in particular adenine, guanine, hypoxanthine, thymine, uracil or cytosine, preferably adenine,
• under racemate or isomeric forms, in particular axial or equatorial isomeric forms, and pharmaceutically acceptable salts thereof.