Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system

A compound of formula I

• wherein
• (R1)(Q)(R2) is selected from the group consisting of
• (O)(bond)(S(O)2),
• ([18F]fluoro)(blank)(S(O)2(O−)(X+)),
• (F)(blank)(S(O)2(O−)(X+)),
• ([18F]fluoro)(blank)(H), and
• (F)(blank)(H);
• X+ is selected from the group consisting of Li+, Na+, K+, Cs+, and/or Rb+;
• bond means that the atoms or atom groups adjacent to the bond share at least one pair of electrons and thus are chemically bonded to each other;
• blank means that there is neither a chemical bond nor an atom or an atom group connecting R1 and R2.
• including all isomeric forms of said compound, including but not limited to enantiomers and diastereoisomers as well as mixtures of isomers, and any pharmaceutically acceptable salt thereof.

Method for the synthesis of a compound of according to formula I

• wherein
• (R1)(Q)(R2) is selected from the group consisting of
• (O)(bond)(S(O)2),
• ([18F]fluoro)(blank)(S(O)2(O−)(X+)),
• (F)(blank)(S(O)2(O−)(X+)),
• ([18F]fluoro)(blank)(H), and
• (F)(blank)(H);
• X+ is selected from the group consisting of Li+, Na+, K+, Cs+, and/or Rb+;
• bond means that the atoms or atom groups adjacent to the bond share at least one pair of electrons and thus are chemically bonded to each other;
• blank means that there is neither a chemical bond nor an atom or an atom group connecting R1 and R2;
• the method comprising the steps
• converting a compound of formula III
• into a compound of formula IV
• optionally reacting obtained compound of formula IV with a 18F— or 19F-fluorination agent, thereby obtaining a compound of formula Id or Ie,
• wherein X+ is selected from the group consisting of Li+, Na+, K+, Cs+, and/or Rb+,
• optionally reacting obtained compound of formula Ie or Id with acid, thereby obtaining a compound of formula Ia or Ib
• optionally converting obtained compound Ia, Ib, Ic, Id or Ie into a suitable salt of inorganic or organic bases, hydrates, and/or solvates thereof.